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Skincare Ingredients That Work Better Together

Photo by Marevgenna via Adobe Stock.

Perfect Pairs: Skincare Ingredients That Work Better Together →

February 10, 2026

As Valentine’s Day approaches, I thought it would be worthwhile to look at skincare's biggest “power couples.” That is, the skincare ingredients that are known to work together effectively. While minimalism in skincare is often advised, there are instances where combining two products can yield better results than using just one. Skincare “cocktailing” has gained significant popularity, but there’s a right way to combine ingredients. Read on to learn more about these dynamic duos and how to make sure they work together harmoniously.

Sunscreen + Vitamin C

Sunscreen and Vitamin C are a classic duo for daytime skin protection. Vitamin C neutralizes free radicals caused by UV exposure, while sunscreen physically or chemically blocks UV rays. When combined, they significantly reduce sun damage, pigmentation, and early signs of aging. Additionally, layering Vitamin C and sunscreen can enhance your SPF’s effectiveness, providing even better sun protection. To use this combination correctly, be sure to apply your Vitamin C serum before you apply moisturizer and sunscreen.

Niacinamide + Salicylic Acid

If you’re struggling with breakouts, this combination of ingredients is an excellent way to combat dirt, oil, and bacteria without compromising your skin’s natural barrier. Salicylic acid, an oil-soluble chemical exfoliator, penetrates deep into pores to remove dirt, debris, oils, and dead cells that can harbor acne-causing bacteria. Niacinamide, on the other hand, strengthens the skin barrier, which is essential for preventing further bacterial and pollutant entry while retaining essential nutrients and moisture. Additionally, niacinamide has anti-inflammatory properties, treats hyperpigmentation, and regulates sebum production.

You can use salicylic acid (SA) and niacinamide together by layering them. Apply salicylic acid first (after cleansing) to exfoliate, wait a few minutes, and then follow with niacinamide to soothe and control oil. Alternatively, you can reap the benefits of these two ingredients by using them at different times of the day (SA at night and niacinamide in the morning).

Ceramides + Glycolic Acid

Glycolic acid (an exfoliant) and ceramides (barrier-strengthening lipids) make a fantastic skincare duo. Glycolic acid removes dead skin cells, creating a smoother surface for ceramides to penetrate the skin more effectively. Ceramides work to strengthen the skin barrier and reduce irritation. Together, these ingredients result in brighter, smoother, and more hydrated skin. If you’re pairing these ingredients, it’s best to use glycolic acid at night, as it can make your skin more sensitive to the sun. Follow up by treating your skin to a ceramide-based moisturizer to help reinforce your skin’s natural barrier.

AHAs + Hyaluronic Acid

Alpha hydroxy acids (AHAs) are exfoliants that promote cellular renewal, resulting in improved skin texture and radiance. Despite having “acid” in the name, hyaluronic acid is gentle and soothing, as well as hydrating, so it can be used alongside common AHAs such as lactic acid and glycolic acid. Their combination can be beneficial, as hyaluronic acid draws moisture into the skin, helping to mitigate the dryness and irritation that AHAs can sometimes cause.

Retinol + Peptides

Using peptides and retinol together is an excellent anti-aging combination. Retinol accelerates cell turnover, effectively reducing wrinkles and lightening dark spots. Peptides, on the other hand, soothe irritation and fortify the skin barrier, counteracting retinol’s potential to cause dryness. To maximize the benefits of this combination, apply your retinol serum first to clean, dry skin, allowing it to fully absorb. Next, apply a peptide-rich serum or moisturizer to hydrate and repair the skin. Note: While peptides are generally safe to use with retinol, it is best to avoid mixing retinol with copper peptides to prevent potential irritation.


Related:

12 Common Skincare Ingredients and What They Do

Skincare’s Buzziest Ingredients for 2026

In Skincare, Skincare Basics, Skincare Routine, Ingredients Tags Skincare, Skincare Basics, Skincare Routine, Ingredients
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